The absence of players with England, England Saxons, England U20s and Scotland, in addition to a number of injuries, mean that Head Coach Bryan Redpath has had a tough job naming a side this week.
Tindall gets a rare run out at fly half and there is a full debut for Academy winger Ian Clark.
The pack is the one that started last weekend against the Cardiff Blues with the exception of Matt Cox coming in for the injured Brett Deacon at number eight and Darren Dawidiuk replacing Matias Cortese.
The replacements include a welcome return for second row Tom Savage for the first time since mid November and a call up for Billy Burns, younger brother of Freddie, another member of the Academy.
Looking ahead to the game when he addressed the media this week, Redpath admitted that this week presents an unusual challenge.
“It’s going to be pretty tricky at the weekend but it’s just something that we’ve got to get on with.
“With the U20s, Saxons, England and Scotland, it’s just a tough time. And we’ve picked up a few injuries along the way as well.
“You know it’s going to happen so we’ll go into the game and do our best with what we’ve got and not look for any excuses.“
Gloucester are still in the hunt for an LV= Cup semi final place but need the Scarlets to slip up at Sale on Friday evening to have a chance of progressing.
Tom Voyce; Ian Clark, Tim Molenaar, Eliota Fuimaono-Sapolu, James Simpson-Daniel, Mike Tindall, Dave Lewis, Dan Murphy, Darren Dawidiuk, Shaun Knight; Will James, Alex Brown; Peter Buxton (capt), Andy Hazell, Matt Cox
Matias Cortese, Yann Thomas, Dario Chistolini, Tom Savage, Gareth Evans, Nick Runciman, Billy Burns, Akapusi Qera